Advanced Liver Cancer Clinical Trial Pipeline Shows Potential with Active Contributions from 50+ Key Companies | DelveInsight
DelveInsight’s “Advanced Liver Cancer Pipeline Insights 2026” Report provides comprehensive insights about 50+ companies and 52+ pipeline drugs in the advanced liver cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Advanced Liver Cancer therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Explore the comprehensive insights by DelveInsight and stay ahead in understanding the Advanced Liver Cancer Treatment Landscape @ Advanced Liver Cancer Pipeline Outlook
Key Takeaways from the Advanced Liver Cancer Pipeline Report
- On March 09, 2026, AstraZeneca conducted a phase I/II study to evaluate the safety, tolerability, antitumour activity, cellular kinetics, pharmacodynamics, and immunogenicity of AZD5851 in adult participants with GPC3+ advanced/recurrent HCC, where at least one line of prior therapy has failed/or was intolerable, or participant/investigator decision.
- On March 05, 2026, Endeavor Biomedicines Inc. initiated a phase 2 study employing a 2-stage design that aims to evaluate the efficacy and safety of ENV- 101, a potent Hedgehog (Hh) pathway inhibitor, in patients with refractory advanced solid tumors characterized by loss of function (LOF) mutations in the Patched-1 (PTCH1) gene. Stage 1 of this study will enroll approximately 44 patients randomized between two dose levels. As appropriate, Stage 2 of the study will expand enrollment based on the results of Stage 1.
- DelveInsight’s Advanced Liver Cancer pipeline report depicts a robust space with 50+ active players working to develop 52+ pipeline therapies for Advanced Liver Cancer treatment.
- The leading Advanced Liver Cancer Companies such as Can-Fite BioPharma, Polaris Pharmaceuticals, SOTIO Biotech, Surface Oncology, Chia Tai Tianqing Pharmaceutical Group Co., Ltd., AstraZeneca, Takeda, Arbele, ImmVira Pharma Co. Ltd, Vaxcell Bio, Eutilex, Biocity Biopharmaceutics Co., Ltd., Qilu Pharmaceutical Co., Ltd., OriCell Therapeutics Co., Ltd., TORL Biotherapeutics, LLC, Shanghai Henlius Biotech, TaiRx, Inc., Biocity Biopharmaceutics Co., Ltd., and others.
- Promising Advanced Liver Cancer Therapies such as Atezolizumab, Bevacizumab 15 mg/kg, Tiragolumab, Parsaclisib, AV-299, Zimberelimab, Domvanalimab, and others.
Stay informed about the cutting-edge advancements in Advanced Liver Cancer treatments @ Advanced Liver Cancer Clinical Trials Assessment
Advanced Liver Cancer Overview
Advanced liver cancer, characterized by its progression to later stages, represents a formidable medical challenge due to its propensity for metastasis and the intricate interplay of factors influencing disease progression. At this advanced stage, the cancer has typically infiltrated surrounding tissues and organs, disrupting normal liver function and potentially impacting vital bodily processes. Metastasis, often widespread by this point, can occur in various distant sites beyond the liver, including the lungs, bones, lymph nodes, and other regions, exacerbating the complexity of disease management.
Advanced Liver Cancer Emerging Drugs Profile
- Namodenoson: Can-Fite BioPharma
Namodenoson is an oral small molecule drug generically known as Cl-IB-MECA (2-chloro-N6-(3-iodobenzyl)-adenosine-5′- N-methyl-uronamide), a highly specific and selective agonist at the A3 adenosine receptor (A3AR). Namodenoson’s mechanism of action is mediated via deregulation of the NF-?B and Wnt signal transduction pathways, resulting in the apoptosis of tumor cells. The protective effect of Namodenoson is mediated via down-regulation of the NF-kB signal transduction pathway and preventing apoptosis. Namodenoson has a potent anti-cancer effect, particularly against hepatocellular carcinoma, and anti-inflammatory activity demonstrated in pre-clinical animal models of liver inflammation. Currently, the drug is in Phase III stage of its development for the treatment of Advanced liver Cancer.
- ADI-PEG20: Polaris Pharmaceuticals
Pegylated arginine deiminase (ADI-PEG20) is a novel anticancer enzyme that produces depletion of arginine, which is a nonessential amino acid in humans. Certain tumors, such as malignant melanoma and hepatocellular carcinoma, are auxotrophic for arginine. These tumors that are sensitive to arginine depletion do not express argininosuccinate synthetase, a key enzyme in the synthesis of arginine from citrulline. ADI-PEG20 appears to show inhibitory effects on human melanomas and hepatocellular carcinomas. Currently, the drug is in Phase III stage of its development for the treatment of Advanced liver Cancer.
- SRF388: Surface Oncology
SRF388 is a fully human IgG1 blocking antibody to IL-27 with potential to promote immune activation in the tumor microenvironment. The immunoregulatory cytokine IL-27 upregulates inhibitory immune checkpoint receptors (eg, PD-L1, TIGIT) and downregulates proinflammatory cytokines (eg, IFN?, TNFa). Currently, the drug is in the Phase II stage of development to treat Advanced liver cancer.
- TQB2223: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
TQB2223 is a recombinant, fully human antibody that binds to lymphocyte activation gene-3 (LAG-3) and blocks the LAG-3/ major histocompatibility complex class II (MHC-II) interaction, thus allowing for increased T-cell proliferation and cytokine production. Currently, the drug is in the Phase I stage of development to treat Advanced liver cancer.
Learn more about Advanced Liver Cancer Drugs opportunities in our groundbreaking Advanced Liver Cancer Research and development projects @ Advanced Liver Cancer Unmet Needs
Advanced Liver Cancer Companies
Can-Fite BioPharma, Polaris Pharmaceuticals, SOTIO Biotech, Surface Oncology, Chia Tai Tianqing Pharmaceutical Group Co., Ltd., AstraZeneca, Takeda, Arbele, ImmVira Pharma Co. Ltd, Vaxcell Bio, Eutilex, Biocity Biopharmaceutics Co., Ltd., Qilu Pharmaceutical Co., Ltd., OriCell Therapeutics Co., Ltd., TORL Biotherapeutics, LLC, Shanghai Henlius Biotech, TaiRx, Inc., Biocity Biopharmaceutics Co., Ltd, and others.
Advanced liver cancer pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
- Oral
- Intravenous
- Subcutaneous
- Parenteral
- Topical
Advanced Liver Cancer Products have been categorized under various Molecule types such as
- Recombinant fusion proteins
- Small molecule
- Monoclonal antibody
- Peptide
- Polymer
- Gene therapy
Discover the latest advancements in Advanced Liver Cancer treatment by visiting our website @ Advanced Liver Cancer Market Drivers and Barriers, and Future Perspectives
Scope of the Advanced Liver Cancer Pipeline Report
- Coverage- Global
- Advanced Liver Cancer Companies- Can-Fite BioPharma, Polaris Pharmaceuticals, SOTIO Biotech, Surface Oncology, Chia Tai Tianqing Pharmaceutical Group Co., Ltd., AstraZeneca, Takeda, Arbele, ImmVira Pharma Co. Ltd, Vaxcell Bio, Eutilex, Biocity Biopharmaceutics Co., Ltd., Qilu Pharmaceutical Co., Ltd., OriCell Therapeutics Co., Ltd., TORL Biotherapeutics, LLC, Shanghai Henlius Biotech, TaiRx, Inc., Biocity Biopharmaceutics Co., Ltd., and others.
- Advanced Liver Cancer Therapies- Atezolizumab, Bevacizumab 15 mg/kg, Tiragolumab, Parsaclisib, AV-299, Zimberelimab, Domvanalimab, and others.
- Advanced Liver Cancer Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
- Advanced Liver Cancer Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
Read the full details of Advanced Liver Cancer Pipeline on our website @ Advanced Liver Cancer Emerging Drugs and Companies
Table of Content
- Introduction
- Executive Summary
- Advanced liver cancer: Overview
- Pipeline Therapeutics
- Therapeutic Assessment
- Advanced liver cancer– DelveInsight’s Analytical Perspective
- Late Stage Products (Phase III)
- Namodenoson: Can-Fite BioPharma
- Drug profiles in the detailed report…..
- Mid Stage Products (Phase II)
- Product Name: Company Name
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I)
- TQB2223: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
- Drug profiles in the detailed report…..
- Preclinical and Discovery Stage Products
- Drug name: Company name
- Drug profiles in the detailed report…..
- Inactive Products
- Advanced liver cancer Key Companies
- Advanced liver cancer Key Products
- Advanced liver cancer- Unmet Needs
- Advanced liver cancer- Market Drivers and Barriers
- Advanced liver cancer- Future Perspectives and Conclusion
- Advanced liver cancer Analyst Views
- Advanced liver cancer Key Companies
- Appendix
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